By Erik De Clercq
By way of targeting common molecular mechanisms of antiviral medicines instead of remedies for person viruses, this prepared reference presents the serious wisdom had to boost totally novel therapeutics and to focus on new viruses.It starts with a basic dialogue of antiviral concepts, by means of a large survey of recognized viral goals, equivalent to opposite transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, in addition to their identified inhibitors. the ultimate part comprises numerous instances experiences of modern winning antiviral drug development.Edited by way of Erik de Clercq, the realm authority on small molecule antiviral medicines, who has constructed extra new antivirals than somebody else.
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Extra resources for Antiviral Drug Strategies (Methods and Principles in Medicinal Chemistry, Volume 50)
Journal of Medicinal Chemistry, 50, 1069–1077. , and j25 j 1 Outlook of the Antiviral Drug Era 26 83 84 85 86 87 88 89 90 Snoeck, R. (2007) Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy) propyl]-5-azacytosine: synthesis and antiviral activity. Journal of Medicinal Chemistry, 50, 5765–5772. D. (2006) Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature, 439, 745–748. , and Snoeck, R. (2008) Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2(phosphonomethoxy)propyl]-5azacytosine.
2002) New helicase–primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nature Medicine, 8, 392–398. , and R€ ubsamen-Waigmann, H. (2002) Potent in vivo antiviral activity of the herpes simplex virus primase–helicase inhibitor BAY 57–1293. Antimicrobial Agents and Chemotherapy, 46, 1766–1772. J. (2007) The helicase primase inhibitor, BAY 57-1293 shows potent therapeutic antiviral activity superior to famciclovir in BALB/c mice infected with herpes simplex virus type 1.
2009) Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. The New England Journal of Medicine, 360 1839–1850. , and Simmen, K. (2008) Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorganic & Medicinal Chemistry Letters, 18, 4853–4858. , and Najera, I. (2006) The novel nucleoside analog R1479 (40 azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.